Stem Cell IVF Treatment — Regenerative Medicine Approach
Written & medically reviewed by Dr. Shaivalini Kamarapu
MBBS · MS (Obstetrics & Gynaecology) · Fellowship in Reproductive Medicine · 20+ years of clinical experience
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Stem cell IVF treatment — a regenerative medicine approach
Every woman is born with a fixed number of eggs. As age advances, the number of eggs decreases — leading to difficulty in conception, especially after 35 years of age. In such conditions, donor eggs (from another woman) are an established option. Stem cell therapy is being studied as a possible future option, but it is still experimental: in India it may be offered only within approved clinical research (ICMR guidelines), and no success rate can be promised.
What are stem cells?
Stem cells are cells which have:
Ability of unlimited self renewal
Ability of differentiation (to give rise to a specialised cell type that becomes part of a healthy person)
Multipotent stem cells can be harvested from the bone marrow of the patient.
Types of stem cells
Embryonic
Non-Embryonic
Induced Pluripotent
Techniques used in stem cell treatment
Suspension Technology
Inhibitor Differentiation Method
What are the uses of stem cell therapy in gynaecology?
Conditions in which stem cell therapy is being researched include:
Premature ovarian failure (inability of a woman to form eggs)
Testicular failure (inability of a male to form sperm)
Asherman's syndrome (uterine synechia — when walls of the uterine cavity stick to each other, compromising the cavity space)
What is the role of stem cell therapy in premature ovarian failure?
Stem cell preparation is injected laparoscopically into the ovary. Early research studies have reported an increase in ovarian size and a 2-fold increase in estrogen levels (female hormone levels) for up to 1 year after the procedure.
Relief in symptoms of POF such as hot flushes, night sweats, decreased libido, vaginal dryness, and repeated urinary infections has been seen, leading to enhanced quality of life.